Type 2 Diabetes Mellitus


Diabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood sugar levels, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced. Type 2 DM results from insulin resistance, a condition in which cells fail to respond to the secreted insulin properly, sometimes combined with increasing insulin deficiency.

Today, 380 million people over the world are diagnosed with diabetes, with the disease spreading rapidly and becoming a global epidemic. Patients with diabetes are in higher risk to develop peripheral neuropathy, autonomic neuropathy, macrovascular and microvascular diseases,  excessive and abnormal inflammation and  chronic wounds.

During the last few years it was discovered that type 2 DM is associated with a marked increase in cancer rates. Epidemiological studies have demonstrated that both obesity and type 2 DM are important risk factors for a variety of malignancies. Latest studies show that diabetes increases the risk of development of up to 24 types of cancers. Moreover, type 2 diabetes patients are prone to develop up to 6 fold increase in specific solid cancers, including skin, pancreas, colon and liver. Diabetes patients also respond more poorly to cancer therapy, which is associated with higher mortality. In addition, endogenous insulin levels as well as diabetes drugs can increase cancer risk.